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Welcome to the International PFO Consortium



Newsletter 2015

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The PFO Consortium is approaching the target sample size of 1500 patients!
We would like to thank all centers for their outstanding ongoing effort! A manuscript of a preliminary analysis of the baseline data of 1000 patients is in preparation. So far, we would like to share with you a few details about the collected data:
Patients with closure: 582
New patients since last month: 6
Average age: 59
Ratio male / female: 945 / 558

Oral presentation at the International Stroke Conference in Nashville

In February 2015, results of an interim analysis of our study were presented during the International Stroke Conference 2015 in Nashville (TN). We compared 114 patients with both clinical and radiological evidence of previous stroke with 661 patients with first-­‐ever clinical and radiological stroke. We found that vascular risk factors, age and the antiphospholipid-­‐antibody-­‐syndrom but not TEE features were associated with stroke recurrence in patients with cryptogenic stroke and PFO. The full presentation is attached.

Save the date! 3rd European PFO Summit in Zurich on October 16, 2015
After the great success of the 2nd European PFO Summit, a third one will take place on October 16, 2015 in Zürich, Switzerland. An exciting meeting is being planned. The topics of the main sessions will be: embolic stroke, embolic stroke of unknown source and PFO-­‐related stroke. There will also be two workshops: “Percutaneous closure of PFO” and “Detection of Right-­‐to-­‐Left-­‐Shunt”. The program is attached. You are warmly invited to attend the summit!

New study coordinator
After four years of unparalleled commitment to the PFO consortium, Barbara Mangold is leaving us. Her job will be taken over by Sylvie Nuc. Mrs. Nuc will start her new job in July 2015. Until then, you may contact Marie-­Luise Mono, Executive Director of the PFO Consortium (marie-luise.mono<at> for all questions that might come up with regard to the study. We would like to thank Mrs. Mangold for the excellent work and welcome Mrs. Nuc to her new position.


Welcome to 2013!

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The International PFO Consortium is entering its 6th year! In the past year the consortium was joined by another center in Belgium - making it have 18 active centers.  The study database is soon reaching one thousand enrolled patients. The ratio of closures versus medical treatments is currently 45/55. The study ends with the enrollment of 1500 patients or by the end of 2015.

In 2013, from January 31 to February 1, the PFO Consortium will present its preliminary results at the Swiss Stroke Trialists' Meeting in St. Gallen. In the upcoming summer the Consortium is planning an international stroke summit in Basel, Switzerland.

We wish to all our centers and our partners a successful year!



Invitation to the European PFO Summit

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It is our great pleasure to invite you to Zurich, Switzerland for the European Patent Foramen Ovale (PFO) Summit to be held on October 18, 2013. Organized by the International PFO Consortium in cooperation with the Institute for Medicine and Communication (IMK) AG, the summit aims at bringing together neurologists, interventional cardiologists, cardio- and neurovascular ultrasound technologists, and other specialist sharing a common interest in diagnostic, treatment and prevention of patients with stroke and PFO. Please click here to visit the conference page and register. We are looking forward to seeing you in Zurich very soon!


2011 - A successful year

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We started out in January 2011 with thirteen centers participating at the International PFO Consortium. Now, 11 month later, eighteen hospitals and stroke centers from five countries are engaged in the study. The International PFO Consortium was newly joined by the cantonal hospital of Aarau (Switzerland), the Ammerlandklinik in Westerstede (Germany), the university hospitals in Girona (Spain) and in Ghent (Belgium) and the Mercy Hospital St. Louis (USA).

We welcome the new members to the PFO Consortium and are proud of the further internationalization of the study. Presently, there are close to 700 patients enrolled in the database. We're looking forward to an equally successful 2012 and hope for many more interested hospitals and stroke centers to join the study.

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Last updated on 4.5.2015